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Emerging investigator in Bioinorganic Chemistry

MPI group leader Goran Angelovski develops new magnetic resonance contrast agents


Tübingen, December 18, 2015. The publishing group of the American Chemical Society (ACS Publications) honored 17 emerging investigators who have contributed to recent developments in bioinorganic chemistry. Goran Angelovski, research group leader at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany, is among these emerging investigators. His research is focused on the development of so-called bioresponsive magnetic resonance (MR) contrast agents and methodologies to study brain function using these agents.

 

As stated in the Virtual Issue of this top-publishing society of chemistry research, “the work of the selected emerging investigators is representative of the truly broad nature of the field of bioinorganic chemistry and is at the forefront of the development of new inorganic complexes for diagnostics, medicine, and tools for chemical biology”. The work of the chosen scientists has recently appeared in the ACS journals Inorganic Chemistry, Journal of the American Chemical Society, ACS Chemical Biology or ACS Chemical Neuroscience. 

Research of Goran Angelovski 

His research is aimed at the chemical development of MR contrast agents to monitor various physiological or pathological processes by molecular imaging methods. Successful implementation of these methods will help to provide an understanding of the function of complex biological systems, or aid faster clinical diagnostics of diseases. 

The current research being conducted by the ‘MR Neuroimaging Agents’ group, led by Goran Angelovski, is focused on the development of so-called bioresponsive MR contrast agents and new methodologies to allow the study of brain function. The researchers in his group are preparing MRI compatible molecular sensors, which are capable of changing their signal in the presence of different concentrations of calcium ions or amino-acid neurotransmitters. During brain activity, the concentration of these ions and molecules fluctuate. Consequently, bioresponsive contrast agents report on these changes thus allowing the identification of active brain regions. 

This specific concept exploited by Goran Angelovski and his team has been recognized lately by the specialists in the field, and is the reason for the recent honor.

Biography 

Goran Angelovski studied chemistry at the University of Belgrade in Serbia. In 2000, he moved to Germany and received his doctorate in organic chemistry for synthesis of azamacrocycles at the University of Dortmund as a fellow of German Academic Exchange Service (DAAD). Due to his interest in multidisciplinary research, he joined the Max Planck Institute for Biological Cybernetics in 2005 as a postdoctoral researcher in the department of Prof. Nikos K. Logothetis. He became project leader of the chemistry group in 2007 and from 2009 to 2011 he was also funded by the German Research Foundation (DFG) for his research in ‘smart’ MR contrast agents development. In 2012 he obtained venia legendi (Habilitation) from the Faculty of Natural Sciences in the University of Tübingen. Since 2014 he leads the research group ‘MR Neuroimaging Agents’ at the Max Planck Institute for Biological Cybernetics.

 

More information: 

ACS Select Virtual Issue on Bioinorganic Chemistry

MPI-Research Group: MR Neuroimaging Agents

 

Contact: 

Priv.-Doz. Dr. Goran Angelovski
Tel.: 07071 601- 916
E-Mail: goran.angelovski(at)tuebingen.mpg.de

Christina Bornschein (Public Relations)
Tel.: 07071 601-777
E-Mail: presse-kyb(at)tuebingen.mpg.de 


Goran Angelovski (C)Martin Vötsch / Max Planck Institut für biologische Kybernetik, Tübingen

Goran Angelovski (C)Martin Vötsch / Max Planck Institut für biologische Kybernetik, Tübingen